Pooled analysis of oral microbiome profiles defines robust signatures associated with periodontitis.

ABSTRACT: Oral microbial dysbiosis has been associated with periodontitis in studies using 16S rRNA gene sequencing analysis. However, this technology is not sufficient to consistently separate the bacterial species to species level, and reproducible oral microbiome signatures are scarce. Obtaining these signatures would significantly enhance our understanding of the underlying pathophysiological processes of this condition and foster the development of improved therapeutic strategies, potentially personalized to individual patients. Here, we sequenced newly collected samples from 24 patients with periodontitis, and we collected available oral microbiome data from 24 samples in patients with periodontitis and from 214 samples in healthy individuals (n = 262). Data were harmonized, and we perf

SUBMITTER: Soueidan A 

PROVIDER: S-EPMC11575188 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature