Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.

ABSTRACT:

Background

With increasing incidence and treatment costs, chronic kidney disease (CKD) has become an important public health problem in China, especially in females. However, the genetic determinants are very limited. The estimated glomerular filtration rate (eGFR) based on creatinine is commonly used as a measure of renal function but can be easily affected by other factors. In contrast, eGFR based on both creatinine and cystatin C (eGFRcr-cys) improved the diagnostic accuracy of CKD. To our knowledge, no genome-wide association analysis of eGFRcr-cys has been conducted in the Chinese population.

Methods

By conducting a Genome-Wide association study(GWAS), a method used to identify associations between genetic regions (genomes) and traits/diseases, we examined the relations

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11575226 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature