Integrated analysis of metabolome and microbiome in a rat model of perimenopausal syndrome.

ABSTRACT: The objectives of this study are to examine the disparities in serum and intestinal tissue metabolites between a perimenopausal rat model and control rats and to analyze the diversity and functionality of intestinal microorganisms to determine the potential correlation between intestinal flora and metabolites. We established a rat model of perimenopausal syndrome (PMS) and performed an integrated analysis of metabolome and microbiome. Orthogonal partial least-squares discriminant analysis scores and replacement tests indicated distinct separations of anion and cation levels between serum and intestinal samples of the model and control groups. Furthermore, lipids and lipid-like molecules constituted the largest percentage of HMDB compounds in both serum and intestinal tissues, followed by o

SUBMITTER: Wei Y 

PROVIDER: S-EPMC11575230 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature