Lytic promoter activity during herpes simplex virus latency is dependent on genome location.

ABSTRACT: Herpes simplex virus 1 (HSV-1) is a significant pathogen that establishes lifelong latent infections with intermittent episodes of resumed disease. In mouse models of HSV infection, sporadic low-level lytic gene expression has been detected during latency in the absence of reactivation events that lead to production of new viruses. This viral activity during latency has been reported using a sensitive Cre-marking model for several lytic gene promoters placed in one location in the HSV-1 genome. Here, we extend these findings in the same model by examining first, the activity of an ectopic lytic gene promoter in several places in the genome and second, whether any promoters might be active in their natural context. We found that Cre expression was detected during latency from ectopic

SUBMITTER: Singh N 

PROVIDER: S-EPMC11575402 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature