HCMV strain- and cell type-specific alterations in membrane contact sites point to the convergent regulation of organelle remodeling.

ABSTRACT: Viruses are ubiquitous entities that infect organisms across the kingdoms of life. While viruses can infect a range of cells, tissues, and organisms, this aspect is often not explored in cell culture analyses. There is limited information about which infection-induced changes are shared or distinct in different cellular environments. The prevalent pathogen human cytomegalovirus (HCMV) remodels the structure and function of subcellular organelles and their interconnected networks formed by membrane contact sites (MCSs). A large portion of this knowledge has been derived from fibroblasts infected with a lab-adapted HCMV strain. Here, we assess strain- and cell type-specific alterations in MCSs and organelle remodeling induced by HCMV. Integrating quantitative mass spectrometry, super-resolut

SUBMITTER: Hofstadter WA 

PROVIDER: S-EPMC11575408 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature