Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications.

ABSTRACT: Extracellular vesicles (EVs) have shown great promise as drug delivery system (DDS). However, their complex and costly production limit their development for clinical use. Interestingly, the plant kingdom can also produce EV-like nanovesicles that can easily be isolated and purified from a large quantity of raw material at a high yield. In this study, olive-derived nanovesicles (ODNVs) were isolated from raw fruits using serial centrifugations and their physical and biological features characterized to demonstrate their promising potential to be used as a DDS. Nanotracking particle analysis indicated an average size of 109.5 ± 3.0 nm and yield of 10¹² ODNVs/mL for the purest fraction. Microscopy imaging, membrane fluidity assay and lipidomics analysis showed the presence of a ri

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11575425 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature