Dysfunctional bronchoalveolar effector memory CD8⁺ T cells in tuberculosis-exposed people living with antiretroviral-naive HIV infection.

ABSTRACT: HIV causes susceptibility to respiratory pathogens, including tuberculosis (TB), but the underlying immunological mechanisms remain incompletely understood. We obtained whole blood and bronchoalveolar lavage (BAL) from TB-exposed people in the presence or absence of antiretroviral-naïve HIV co-infection. Bulk transcriptional profiling demonstrated compartment-specific enrichment of immunological processes. Systems-level deconvolution of whole blood from people living with HIV identified elevated type I and type II interferon cytokine activity and T cell proliferation. Transcriptional modules derived from both peripheral blood and sorted BAL immune cells demonstrated an increased frequency of effector memory CD8 T cells in whole BAL samples. Both compartments displayed reduced induction of

SUBMITTER: Mthembu M 

PROVIDER: S-EPMC11575450 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature