Amphoteric β-cyclodextrin coated iron oxide magnetic nanoparticles: new insights into synthesis and application in MRI.

ABSTRACT: This work presents a group of high-quality hydrophilic and negatively charged coated, iron oxide magnetic nanoparticles (MNPs) that have been prepared using a microwave-ultrasound-assisted protocol, and demonstrates the great impact that the synthetic strategy has on the resulting MNPs. The different coatings tested, including citric acid, carboxymethyl dextran and β-cyclodextrin (βCD)/citric acid have been compared and have shown good dispersibility and stability. The ability of βCD to maintain the inclusive properties of the coated MNPs has been proven as well as their cytocompatibility. An amino citrate-modified βCD is proposed and its capabilities as a flexible amphoteric adsorbing device have been studied. The NMR relaxometric properties of the coated MNPs have been investigated using

SUBMITTER: Calsolaro F 

PROVIDER: S-EPMC11575534 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature