Regioselectivity switches between anthraquinone precursor fissions involved in bioactive xanthone biosynthesis.

ABSTRACT: Xanthone-based polyketides with complex molecular frameworks and potent bioactivities distribute and function in different biological kingdoms, yet their biosynthesis remains under-investigated. In particular, nothing is known regarding how to switch between the C_4a-C₁₀ (C_4a-selective) and C_10a-C₁₀ bond (C_10a-selective) cleavages of anthraquinone intermediates involved in biosynthesizing strikingly different frameworks of xanthones and their siblings. Enabled by our characterization of antiosteoporotic brunneoxanthones, a subfamily of polyketides from Aspergillus brunneoviolaceus FB-2, we present herein the brunneoxanthone biosynthetic gene cluster and the C_10a-selective cleavage of anthraquinone (chrysopha

SUBMITTER: Lv XJ 

PROVIDER: S-EPMC11575538 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature