Dual ligand-enabled iron and halogen-containing carboxylate-based photocatalysis for chloro/fluoro-polyhaloalkylation of alkenes.

ABSTRACT: Herein, we demonstrate a practical dual ligand-enabled iron photocatalysis paradigm-converting all kinds of halogen-containing carboxylates (C _n X _m COO^-, X: F, Cl, Br) into C _n X _m radicals for the valuable chloro/fluoro-polyhaloalkylation of non-activated alkenes with easily available trichloroacetonitrile/Selectfluor as the electrophilic halogenation reagent. The modular in situ assembly of the effective iron and C _n X _m COO^--based light-harvesting species using the two ligands-OMe/CF₃-substituted bipyridine and acetonitrile/trichloroacetonitrile is evidenced by detailed mechanistic studies. The late-stage modification, low loading amount of

SUBMITTER: Han W 

PROVIDER: S-EPMC11575577 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature