Viscoelasticity of globular protein-based biomolecular condensates.

ABSTRACT: The phase separation of biomolecules into biomolecular condensates has emerged as a ubiquitous cellular process. Understanding how intrinsically disordered protein sequence controls condensate formation and material properties has provided fundamental biological insights and led to the development of functional synthetic condensates. While these studies provide a valuable framework to understand subcellular organization via phase separation they have largely ignored the presence of folded domains and their impact on condensate properties. We set out to determine how the distribution of sticker interactions across a globular protein contributes to rheological properties of condensates and to what extent globular protein-containing condensates differ from those formed from two disorde

SUBMITTER: Fisher RS 

PROVIDER: S-EPMC11575591 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature