Photoactivated hydride therapy under hypoxia beyond ROS.

ABSTRACT: As compared to oxidative phototherapy, studies on reactive reductive species-participating photodynamic therapy (PDT) are rare. Porphyrins are typical photosensitizers restricted by the oxygen level, but efficacy and selectivity are always incompatible in PDT. Herein, we report that phlorins are ideal hydride (H^-) donors and explore a water-soluble triphenylphosphonium-modified zinc-coordinated porphyrin (^mitoZnPor) for in situ photogeneration of zinc-cored phlorin (^mitoZnPhl). Driven by 1,4-dihydronicotinamide adenine dinucleotide (NADH), the ^mitoZnPor/^mitoZnPhl couple can reduce electron acceptors like iron heme and ubiquinone that play key roles in the mitochondrial electron transport chain (Mito-ETC). Under hypoxia, ^mit

SUBMITTER: Wang X 

PROVIDER: S-EPMC11575613 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature