The PrfA regulon of Listeria monocytogenes is induced by growth in low-oxygen microaerophilic conditions.

ABSTRACT: Listeria monocytogenes is a food-borne pathogen that must adapt to several environments both inside and outside the host. One such environment is the microaerophilic conditions encountered in the host intestine proximal to the mucosal surface. The aim of this study was to investigate the expression of the PrfA regulon in response to microaerophilic growth conditions in the presence of either glucose or glycerol as a carbon source using four transcriptional (Phly, PactA, P/prfA and P/plcA) gene fusions. Further, RNAseq analysis was used to identify global changes in gene expression during growth in microaerophilic conditions. Following microaerophilic growth, there was a PrfA-dependent increase in transcription from the Phly, PactA and P/p

SUBMITTER: Alnakhli LA 

PROVIDER: S-EPMC11575702 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature