Symptom-associated alterations in functional connectivity in primary and secondary provoked vestibulodynia.

ABSTRACT:

Abstract

Primary provoked vestibulodynia (PVD) is marked by the onset of symptoms at first provoking vulvar contact, whereas secondary PVD refers to symptom onset after some period of painless vulvar contact. Different pathophysiological processes are believed to be involved in the development and maintenance of primary PVD and secondary PVD. The primary aim of this study was to test the hypotheses that the resting state functional connectivity of the brain and brain stem regions differs between these subtypes. Deep clinical phenotyping and resting state brain imaging were obtained in a large sample of a women with primary PVD (n = 46), those with secondary PVD (n = 68), and healthy control women (n = 94). The general linear model was used to test for differences in region-to-regio

SUBMITTER: Oughourlian TC 

PROVIDER: S-EPMC11575719 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature