Implementation and evaluation of a dynamic contrast-enhanced MR perfusion protocol for glioblastoma using a 0.35 T MRI-Linac system.

ABSTRACT:

Purpose

MRI-linear accelerator (MRI-Linac) systems allow for daily tracking of MRI changes during radiotherapy (RT). Since one common MRI-Linac operates at 0.35 T, there are efforts towards developing protocols at that field strength. In this study we demonstrate the implementation of a post-contrast 3DT1-weighted (3D-T1w) and dynamic contrast-enhancement (DCE) protocol to assess glioblastoma response to RT using a 0.35 T MRI-Linac.

Methods and materials

The protocol implemented was used to acquire 3D-T1w and DCE data from a flow phantom and two patients with glioblastoma (a responder and a non-responder) who underwent RT on a 0.35 T MRI-Linac. The detection of post-contrast-enhanced volumes was evaluated by comparing the 3DT1w images from the 0.35 T MRI-Linac to images obta

SUBMITTER: Maziero D 

PROVIDER: S-EPMC11575850 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature