Multicenter Hemodynamic Assessment of the LOT-CRT Strategy: When Does Combining Left Bundle Branch Pacing and Coronary Venous Pacing Enhance Resynchronization?: Primary Results of the CSPOT Study.

ABSTRACT:

Background

Left bundle branch area pacing (LBBAP) may be an alternative to biventricular pacing (BVP) for cardiac resynchronization therapy (CRT). We sought to compare the acute hemodynamic and ECG effects of LBBAP, BVP, and left bundle-optimized therapy CRT (LOT-CRT) in CRT candidates with advanced conduction disease.

Methods

In this multicenter study, 48 patients with either nonspecific interventricular conduction delay (n=29) or left bundle branch block (n=19) underwent acute hemodynamic testing to determine the change in left ventricular pressure maximal first derivative (LV dP/dt_max) from baseline atrial pacing to BVP, LBBAP, or LOT-CRT.

Results

Atrioventricular-optimized increases in LV dP/dt_max for LOT-CRT (mean

SUBMITTER: Jastrzebski M 

PROVIDER: S-EPMC11575906 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature