Gene prediction of the causal relationship between immune cells and IgA nephropathy: A bidirectional Mendelian randomization study.

ABSTRACT: IgA nephropathy is the most common primary glomerular disease worldwide, with inflammation and autoimmune response mechanisms permeating the entire disease development process. The advancement of genome-wide association studies has enabled deeper understanding of the disease mechanisms and genetic susceptibility. Therefore, this study aims to explore the causal relationship between 731 immune cell types and the disease through Mendelian randomization (MR) analysis. This 2-sample MR study investigated bidirectional causal relationships using summary statistics for immune cells characteristics from the Genome-Wide Association Study (GWAS) catalog and IgA nephropathy from the FinnGen dataset. The study primarily utilized the Inverse Variance Weighted method for its main outcome. Additionally,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11575961 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature