Iron Administration Partially Ameliorates Cadmium-Induced Oxidative Damage in the Liver and Kidney of Rats.

ABSTRACT: The protective effect of Fe against Cd-induced toxicity in the liver and kidney of rats during concurrent administration of both metals was investigated in this study. Fifty female rats (130-150 g) were distributed into five groups of 10 rats each (n = 10): Group I (control), received normal saline solution; Group II (1.2 mg CdCl₂/kg b.w.); Group III (1.2 mg CdCl₂ + 0.25 mg FeCl₂/kg b.w.); Group IV (1.2 mg CdCl₂ + 0.75 mg FeCl₂/kg b.w.); and Group V (1.2 mg CdCl₂ + 1.5 mg FeCl₂/kg b.w.). Administration of both tested substances lasted for 47 days. Cd was injected intraperitoneally once a week, while Fe was administered to the Cd-exposed animals by oral gavage thrice weekly. The animals were killed at the en

SUBMITTER: Ezim OE 

PROVIDER: S-EPMC11576088 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature