Menopause age and type and dementia risk: a pooled analysis of 233 802 women.

ABSTRACT:

Objectives

It is not clear whether the association between younger age at menopause and increased risk of dementia is modified by type of menopause. We examined the association of age at menopause or hysterectomy with dementia risk in three groups of women: those with natural menopause, premenopausal bilateral oophorectomy (surgical menopause) or premenopausal hysterectomy (without bilateral oophorectomy).

Study design

Individual-level data from 233 802 women in five prospective cohort studies (from four countries) were harmonized and pooled. Cox proportional hazards models were used to assess the associations of age at natural menopause, surgical menopause or premenopausal hysterectomy, with age at dementia, death (where available) or end of follow-up, whichever came first.

SUBMITTER: Dobson AJ 

PROVIDER: S-EPMC11576136 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature