Genomic characterization of clinically significant blood group variants in Aboriginal Australians.

ABSTRACT:

Background

Hematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for transfusion. There is a scarcity of knowledge regarding blood group variants in Aboriginal Australian populations, despite a higher need for transfusion due to the higher prevalence of renal diseases and anemia.

Materials and methods

In this study, we applied next-generation sequencing and analysis to 245 samples obtained from Aboriginal Australians from South-East Queensland, to predict antigen phenotypes for 36 blood group systems.

Results

We report potential weak antigens in blood group systems RH, FY and JR that have po

SUBMITTER: Jadhao S 

PROVIDER: S-EPMC11576151 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature