Rare and common variants associated with alcohol consumption identify a conserved molecular network.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified hundreds of common variants associated with alcohol consumption. In contrast, genetic studies of alcohol consumption that use rare variants are still in their early stages. No prior studies of alcohol consumption have examined whether common and rare variants implicate the same genes and molecular networks, leaving open the possibility that the two approaches might identify distinct biology.

Methods

To address this knowledge gap, we used publicly available alcohol consumption GWAS summary statistics (GSCAN, N = 666,978) and whole exome sequencing data (Genebass, N = 393,099) to identify a set of common and rare variants for alcohol consumption. We used gene-based analysis to implicate genes from common and rar

SUBMITTER: Leger BS 

PROVIDER: S-EPMC11576244 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature