Clinical application of chromosome microarray analysis and karyotyping in prenatal diagnosis in Northwest China.

ABSTRACT:

Introduction

Karyotyping and chromosome microarray analysis (CMA) are the two main prenatal diagnostic techniques currently used for genetic testing. We aimed to evaluate the value of chromosomal karyotyping and CMA for different prenatal indications.

Methods

A total of 2084 amniocentesis samples from pregnant women who underwent prenatal diagnosis from 16 to 22 + 6 weeks of gestation between January 2021 and December 2022 were retrospectively collected. The pregnant women were classified according to different prenatal diagnostic indications and underwent CMA and karyotype analysis. Clinical data were collected, and the results of the CMA and karyotype analysis were statistically analyzed to compare the effects of the two diagnostic techniques.

Results

The total dete

SUBMITTER: Xue S 

PROVIDER: S-EPMC11576268 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature