Magnetic particle imaging enables nonradioactive quantitative sentinel lymph node identification: feasibility proof in murine models.

ABSTRACT:

Background

Sentinel lymph node biopsy (SLNB) is an important cancer diagnostic staging procedure. Conventional SLNB procedures with ^99mTc radiotracers and scintigraphy are constrained by tracer half-life and, in some cases, insufficient image resolution. Here, we explore an alternative magnetic (nonradioactive) image-guided SLNB procedure.

Purpose

To demonstrate that magnetic particle imaging (MPI) lymphography can sensitively, specifically, and quantitatively identify and map sentinel lymph modes (SLNs) in murine models in multiple regional lymphatic basins.

Materials and methods

Iron oxide nanoparticles were administered intradermally to healthy C57BL/6 mice (male, 12-week-old, n = 5). The nanoparticles (0.675 mg Fe/kg) were injected into the tongue, fore

SUBMITTER: Sehl OC 

PROVIDER: S-EPMC11576474 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature