Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection.

ABSTRACT:

Background

Human immune responses to infection and vaccination are heterogenous, driven by multiple factors including genetics, environmental exposures and personal infection histories. For malaria caused by Plasmodium falciparum parasites, host factors that impact on humoral immunity are poorly understood.

Methods

We investigated the role of latent cytomegalovirus (CMV) on the host immune response to malaria using samples obtained from individuals in previously conducted Phase 1 trials of blood stage P. falciparum Controlled Human Malaria Infection (CHMI) and in a MSP1 vaccine clinical trial. Induced antibody and functions of antibodies, as well as CD4 T cell responses were quantified.

Findings

CMV seropositivity was associated with reduced induction of parasite spec

SUBMITTER: Mukhiya R 

PROVIDER: S-EPMC11576503 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature