Effects of Aging on Intrinsic Protein Disorder in Human Lenses and Zonules.

ABSTRACT: This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey's HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and in

SUBMITTER: Antonietti M 

PROVIDER: S-EPMC11576620 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature