Identifying the genetic association between severe autoimmune type 2 diabetes and the risk of focal epilepsy.

ABSTRACT:

Background

Observational studies suggested a bidirectional relationship between severe autoimmune type 2 diabetes and focal epilepsy. However, it remains debated whether and in which direction a causal association exists. This genetics-based study aimed to explore the relationships of severe autoimmune type 2 diabetes (T2DM) and focal epilepsy outcomes with two sample Mendelian randomization (TSMR) method.

Methods

Genetic instruments were obtained from large-scale genome-wide meta-analysis of severe autoimmune T2DM (Ncase = 452, Ncontrol = 2,744), and focal epilepsy (Ncase = 929, Ncontrol = 212,532) of European ancestry. A series of analyses were performed to select eligible genetic instruments robustly associated with each of the traits using summary-level statistics. Inver

SUBMITTER: Wu H 

PROVIDER: S-EPMC11576724 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature