First-in-human study of ^99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin.

ABSTRACT:

Background

Activation of endothelial cells and platelets in atherothrombosis is characterized by upregulation of P-selectin. As a consequence, P-selectin represents a potential target for molecular imaging to identify thrombosis at an early stage. Fucoidan is a polysaccharide ligand extracted from brown algae with nanomolar affinity for P-selectin. This first-in-human study evaluated in healthy volunteers the safety, whole-body biodistribution, and dosimetry of ^99mTc-fucoidan (Good Manufacturing Practices grade). We also investigated whether we could observe binding of ^99mTc-fucoidan to human thrombi ex vivo and in vivo. In ten healthy volunteers, conjugate whole-body scans were performed up to 24 h following intravenous injection of ^99mTc-fucoidan

SUBMITTER: Oostveen RF 

PROVIDER: S-EPMC11576749 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature