Effects and mechanisms of dexmedetomidine preconditioning on isoproterenol-induced ventricular arrhythmias.

ABSTRACT: Dexmedetomidine (DEX) is commonly used in clinical practice because of its sedative, analgesic, antisympathetic, hemodynamic stabilization and antianxiety effects. Previous clinical studies have demonstrated that DEX plays a role in both the prevention and treatment of perioperative arrhythmias. However, the precise mechanisms underlying the effects of DEX remain unclear. Furthermore, few studies have examined the effect of DEX on cardiac electrophysiology. ECG recording was performed in vivo and ex vivo on C57 mice. Simultaneous recording of membrane voltage (Vm) and [Ca²⁺]i changes was achieved with dual-dye optical mapping, in which voltage- and Ca²⁺-sensitive dyes are employed. Simultaneous programmed electrical stimulation was used to pacing and induce arrhythmia

SUBMITTER: Duan S 

PROVIDER: S-EPMC11576759 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature