Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks.

ABSTRACT: The genetic structure in Europe was mostly shaped by admixture between the Western Hunter-Gatherers, Early European Farmers and Steppe Bronze Age ancestral components. Such structure is regarded as a confounder in GWAS and follow-up studies, and gold-standard methods exist to correct for it. However, it is still poorly understood to which extent these ancestral components contribute to complex trait variation in present-day Europe. In this work we harness the UK Biobank to address this question. By extensive demographic simulations, exploiting data on siblings and incorporating previous results we obtained from the Estonian Biobank, we carefully evaluate the significance and scope of our findings. Heart rate, platelet count, bone mineral density and many other traits show stratification si

SUBMITTER: Pankratov V 

PROVIDER: S-EPMC11576899 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature