The effects of extracellular matrix-degrading enzymes polymorphisms on intervertebral disc degeneration.

ABSTRACT:

Objective

The objective of the current study was to investigate the correlation between polymorphisms in extracellular matrix-degrading enzymes and the risk of intervertebral disc degeneration (IDD) diseases.

Methods

The databases PubMed, Embase, and Cochrane Database were systematically queried from the inception until March 2023 to ascertain studies that meet the eligibility criteria. Utilizing a standardized data collection form to extract data from individual studies. The data were quantified using odds ratio (OR) along with its corresponding 95% confidence interval (95% CI), following an allelic model of inheritance.

Results

The study included a total of nine studies and indicated that the presence of rs17576 in the MMP9 gene was significantly associated with an

SUBMITTER: Zhao D 

PROVIDER: S-EPMC11576917 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature