Association between proton pump inhibitors and dementia risk: a Mendelian randomization study.

ABSTRACT: Numerous observational studies suggest associations between proton pump inhibitors (PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome-wide association study (GWAS) data, we performed univariable Mendelian randomization (UVMR) analysis to assess the causality between five PPI types, and all-cause dementia and its five subtypes. Confounders were controlled through multivariable MR (MVMR) analysis to isolate PPIs' direct effects on dementia. Heterogeneity and pleiotropy assessments, and leave-one-out analysis, were conducted to validate the robustness of our results. Initial UVMR estimates suggested that lansoprazole (odds ratio [OR] 1.291; 95%confidence interval [CI] 1.001-1.665; p = 0.049) and pantoprazole (OR 1.118; 95% CI 1.014-1.233; p = 0.025) poten

SUBMITTER: Xie K 

PROVIDER: S-EPMC11576989 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature