Multimodal assessment of brain stiffness variation in healthy subjects using magnetic resonance elastography and ultrasound time-harmonic elastography.

ABSTRACT: Magnetic resonance elastography (MRE) is a noninvasive brain stiffness mapping method. Ultrasound-based transtemporal time-harmonic elastography (THE) is emerging as a cost-effective, fast alternative that has potential applications for bedside monitoring of intracranial pressure. We aim to investigate the accuracy of THE in comparison to MRE performed in the brain. Ten healthy volunteers (25-40 years old) underwent multifrequency MRE (20-35 Hz) and THE (27-56 Hz). Fiducial-marker-based optical tracking of the ultrasound field of view was used to align THE to 3D MRE. THE- and MRE-derived shear wave speed (SWS) was determined as a measure of brain stiffness and averaged within regions of various depths for cross-modality correlation analysis. MRE-measured SWS ranged from 1.0 to 1.3 m/s and

SUBMITTER: Klemmer Chandia S 

PROVIDER: S-EPMC11576992 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature