Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer.

ABSTRACT:

Background

There may be potential associations between various pathogens, antibody immune responses, and breast cancer (BC), but the specific mechanisms and causal relationships remain unclear.

Methods

First, multiple Mendelian randomization (MR) methods were used for univariable MR analysis to explore potential causal relationships between 34 antibody immune responses (related to 12 pathogens), 46 antibody immune responses (related to 13 pathogens), antibody responses post-COVID-19 vaccination, 731 immune cell types, and various BC subtypes (including overall BC, ER-positive, ER-negative, Luminal A, Luminal B, Luminal B HER2-negative, HER2-positive, and triple-negative BC). The primary results were then subjected to reverse MR analysis, heterogeneity testing using Cochran's

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11577091 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature