Associations between dairy and alcohol consumption and major depressive disorder in a mendelian randomization study.

ABSTRACT: This study explored the link between diet and major depressive disorder (MDD) to provide fresh insights for MDD prevention. Single nucleotide polymorphisms (SNPs) associated with common foods, such as meat, bread, cheese, fruits, cereals, vegetables, and four alcohol intake categories, were leveraged as instrumental variables. Accordingly, this study employed the inverse variance weighting (IVW) method to evaluate the genetically predicted associations of different food phenotypes with MDD risk. The sensitivity analysis involved MR‒Egger regression and Mendelian random polymorphism residuals, along with outlier tests, to assess instrumental variable pleiotropy. Additional analysis methods, such as MR‒Egger, the weighted median method, and the weighted model, were used to validate the robus

SUBMITTER: Qiu D 

PROVIDER: S-EPMC11577118 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature