Discontinuation of Cholinesterase Inhibitors Following Initiation of Memantine and Admission to Long-Term Care Among Older Adults.

ABSTRACT:

Importance

Discontinuing cholinesterase inhibitors when initiating memantine in patients with dementia may be reasonable to reduce treatment burden, costs, and the risk of adverse drug events.

Objective

To assess the association of cholinesterase inhibitor discontinuation on long-term care institutionalization among older adults with dementia who initiate memantine.

Design, setting, and participants

This retrospective propensity score-matched cohort study used Medicare claims data from January 2014 to December 2019. Participants included fee-for-service Medicare beneficiaries with dementia. Data were analyzed from September 2021 to August 2024.

Exposures

Discontinuation vs continuation of cholinesterase inhibitor.

Main outcomes and measures

The primary o

SUBMITTER: Lee YC 

PROVIDER: S-EPMC11577138 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature