Genetic Characteristics of Cutaneous, Acral, and Mucosal Melanoma in Japan.

ABSTRACT:

Background

Acral and mucosal melanomas are more prevalent in Asians than in Caucasians, unlike cutaneous melanomas, which are predominant in Caucasians. Recent studies have suggested that non-Caucasian cutaneous melanomas responded less to immune checkpoint inhibitors, highlighting the need for genetic profiling across ethnicities. This study aimed to elucidate the genetic characteristics of Japanese melanomas, which is an under-researched topic.

Methods

Single-nucleotide variants, indels, and copy number alterations in 104 Japanese melanoma patients (37 cutaneous, 52 acral, and 15 mucosal) were analyzed using custom panel sequencing.

Results

Driver events were detected in 94% of the cases. Among cutaneous melanoma cases, 76% had BRAF mutations, and 8% had NRAS mutati

SUBMITTER: Hida T 

PROVIDER: S-EPMC11577301 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature