Glycocalyx Interactions Modulate the Cellular Uptake of Albumin-Coated Nanoparticles.

ABSTRACT: Albumin-based nanoparticles (ABNPs) represent promising drug carriers in nanomedicine due to their versatility and biocompatibility, but optimizing their effectiveness in drug delivery requires understanding their interactions with and uptake by cells. Notably, albumin interacts with the cellular glycocalyx, a phenomenon particularly studied in endothelial cells. This observation suggests that the glycocalyx could modulate ABNP uptake and therapeutic efficacy, although this possibility remains unrecognized. In this study, we elucidate the critical role of the glycocalyx in the cellular uptake of a model ABNP system consisting of silica nanoparticles (NPs) coated with native, cationic, and anionic albumin variants (BSA, BSA+, and BSA-). Using various methodologies-including fluorescence ani

SUBMITTER: Olivieri PH 

PROVIDER: S-EPMC11577421 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature