The efficacy and safety of a simple 14-day vonoprazan-minocycline dual therapy for <i>Helicobacter pylori</i> eradication: a retrospective pilot study.

ABSTRACT:

Background

Current eradication regimens are not ideal for Helicobacter pylori infected patients who have difficulty choosing antibiotics due to penicillin allergy or antibiotic resistance.

Objective

To explore the efficacy and safety of a simple vonoprazan-minocycline dual therapy (VM dual therapy) in H. pylori eradication.

Design

Clinical data of patients who were prescribed 14-day VM dual therapy were retrospectively collected. The included patients were 18-70 years old and positive for ¹³C urea breath test (¹³C-UBT). They were allergic to penicillin or had a history of repeated antibiotic exposure or had failed eradication with multiple regimens containing amoxicillin. VM dual therapy consists of vonoprazan 20 mg twice daily and

SUBMITTER: Wang X 

PROVIDER: S-EPMC11577453 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature