Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study.

ABSTRACT:

Objective

To prospectively assess the effect of endometriosis and uterine fibroids on the long term risk of premature mortality (younger than 70 years).

Design

Prospective cohort study SETTING: The Nurses' Health Study II, United States (1989-2019).

Participants

110 091 women aged 25-42 years in 1989 without a history of hysterectomy before endometriosis or fibroids diagnosis, cardiovascular diseases, or cancer.

Main outcome measures

Hazard ratios (estimated by Cox proportional hazards models) for total and cause specific premature mortality according to laparoscopically confirmed endometriosis or ultrasound or hysterectomy confirmed uterine fibroids reported in biennial questionnaires.

Results

4356 premature deaths were recorded during 2 994 354 person

SUBMITTER: Wang YX 

PROVIDER: S-EPMC11577545 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature