G protein-coupled receptor 91 promotes the inflammatory response to <i>Porphyromonas gingivalis</i> in bone marrow-derived macrophages.

ABSTRACT: Macrophages are important for maintaining tissue homeostasis and defending against pathogens in periodontal tissues. However, these tissues are often vulnerable to damage due to local inflammatory responses within the host tissues. This study aimed to investigate the role of G protein-coupled receptor 91(GPR91) during the inflammatory response to Porphyromonas gingivalis (P. gingivalis) in bone marrow-derived macrophages (BMDMs). To this end, we examined expression levels of GPR91 genes in human periodontal tissues affected by periodontitis. Utilizing primary mouse BMDMs from wild-type (WT) and GPR91 knockout (GPR91^-/-) mice infected with P. gingivalis, we demonstrated that GPR91 accumulates in inflamed gingival tissues. Additionally, P. gingivalis ca

SUBMITTER: Su W 

PROVIDER: S-EPMC11577564 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature