Supplementation with inulin reverses cognitive flexibility alterations and modulates the gut microbiota in high-fat-fed mice.

ABSTRACT:

Introduction

Alterations in cognitive performance are associated with inadequate nutritional states and diet composition. Prebiotics, such as inulin, are substances that can modulate the gut microbiome and, consequently, brain function by producing metabolites such as short-chain fatty acids (SCFAs). This study aimed to evaluate the effect of supplementation with inulin on cognitive flexibility, body composition, and gut microbiota in a murine model exposed to a high-fat (HF) diet.

Methods

CD1 mice were divided into five groups: control fed a standard diet (C), high-fat diet (HF), inulin (I), high-fat diet with inulin (HFI), and manipulation control (M). Dietary supplementation was administered for 6 weeks. Cognitive flexibility was assessed using the Attentional Set-Shiftin

SUBMITTER: Gonzalez-Velazquez G 

PROVIDER: S-EPMC11577567 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature