Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is caused by interactions between many factors across the life course, including genetics. A proportion of COPD may be due to reduced lung growth in childhood. We hypothesized that a polygenic risk score (PRS) for COPD is associated with lower lung function already in childhood and up to adulthood.

Methods

A weighted PRS was calculated based on the 82 association signals (p ≤ 5 × 10^-8) revealed by the largest GWAS of airflow limitation (defined as COPD) to date. This PRS was tested in association with lung function measures (FEV₁, FVC, and FEV₁/FVC) in subjects aged 4-50 years from 16 independent cohorts participating in the Chronic Airway Diseases Early Stratification (CADSET) Cl

SUBMITTER: Hernandez-Pacheco N 

PROVIDER: S-EPMC11577569 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature