Regulation of Kv1.2 Redox-Sensitive Gating by the Transmembrane Lectin LMAN2.

ABSTRACT: Voltage gated potassium (Kv)1.2 channels influence excitability and action potential propagation in the nervous system. Unlike closely related Kv1 channels, Kv1.2 exhibits highly variable voltage-dependence of gating, attributed to regulation by unidentified extrinsic factors. Variability of Kv1.2 gating is strongly influenced by the extracellular redox potential, and we demonstrate that Kv1.2 currents in dorsal root ganglion sensory neurons exhibit similar variability and redox sensitivity as observed when the channel is heterologously expressed in cell lines. We used a functional screening approach to test the effects of candidate regulatory proteins on Kv1.2 gating, using patch clamp electrophysiology. Among 52 candidate genes tested, we observed that co-expression with the transmembran

SUBMITTER: Lamothe SM 

PROVIDER: S-EPMC11577617 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature