Barriers and facilitators to enrollment in pediatric clinical trials: an overview of systematic reviews.

ABSTRACT:

Background

Recruiting a sufficient number of patients is often a challenge for conducting clinical trials. Published data reveal that only 10% of eligible patients according to inclusion and exclusion criteria are enrolled in clinical trials. Consequentially, identifying barriers and facilitators may improve enrollment. These factors may differ in the pediatric population, for example, due to the involvement of parents in the decision-making process. We aimed to conduct an overview of systematic reviews to summarize the barriers and facilitators influencing the enrollment of pediatric participants in clinical trials.

Methods

A systematic literature search in PubMed and Epistemonikos of published systematic reviews focusing on barriers and facilitators influencing the enrollm

SUBMITTER: Bencheva V 

PROVIDER: S-EPMC11577732 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature