<i>sll1019</i> and <i>slr1259</i> encoding glyoxalase II improve tolerance of <i>Synechocystis</i> sp. PCC 6803 to methylglyoxal- and ethanol- induced oxidative stress by glyoxalase pathway.

ABSTRACT: The glyoxalase pathway is the primary detoxification mechanism for methylglyoxal (MG), a ubiquitous toxic metabolite that disrupts redox homeostasis. In the glyoxalase pathway, glyoxalase II (GlyII) can completely detoxify MG. Increasing the activity of the glyoxalase system can enhance the resistance of plants or organisms to abiotic stress, but the relevant mechanism remains largely unknown. In this study, we investigated the physiological functions of GlyII genes (sll1019 and slr1259) in Synechocystis sp. PCC 6803 under MG or ethanol stress based on transcriptome and metabolome data. High-performance liquid chromatography (HPLC) results showed that proteins Sll1019 and Slr1259 had GlyII activity. Under stress conditions, sll1019 and slr1259 protected t

SUBMITTER: Ji K 

PROVIDER: S-EPMC11577758 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature