Differential expression of the <i>yfj</i> operon in a <i>Bacillus subtilis</i> biofilm.

ABSTRACT: Type VII protein secretion systems play an important role in the survival and virulence of pathogens and in the competition among some microbes. Potential polymorphic toxin substrates of the type VII secretion system (T7SS) in Bacillus subtilis are important for competition in the context of biofilm communities. Within a biofilm, there is significant physiological heterogeneity as cells within the population take on differential cell fates. Which cells express and deploy the various T7SS substrates is still unknown. To identify which cells express at least one of the T7SS substrates, we investigated the yfj operon. The yfjABCDEF operon encodes at least one predicted T7SS substrate. Starting with an in silico analysis of the yfj operon promoter region, we

SUBMITTER: Finn JP 

PROVIDER: S-EPMC11577775 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature