Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies.

ABSTRACT: Fungi generate a diverse array of bioactive compounds with significant pharmaceutical applications. However, the chemical diversity of natural products in fungi remains largely unexplored. Here, we present a paradigm for specifically discovering diverse and bioactive compounds from fungi by integrating genome mining with building block molecular network and coculture analysis. Through pangenome and sequence similarity network analysis, we identified a rare type I polyketide enzyme from Penicillium sp. ZJUT-34. Subsequent building block molecular network and coculture strategy led to the identification and isolation of a pair of novel polyketides, (±)-peniphenone E [(±)-1], three known polyketides (2-4), and three precursor compounds (5-7) from a combined culture

SUBMITTER: Wang C 

PROVIDER: S-EPMC11577776 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature