Cognotoxemia: endotoxemia and gender predict changes in working memory performance in healthy adults.

ABSTRACT:

Introduction

Examining the contribution of peripheral systems to cognitive function under healthy circumstances may improve our understanding of the systems that confer risk or resilience in diseased states. Endotoxemia-a pro-inflammatory response to the translocation of bacteria that reside in the gut on other sources (e.g., respiratory tract; infection) into the blood-was hypothesized to relate to worsened cognitive functioning. Gender was explored as a moderator.

Methods

A sample of 162 healthy adults (25-65 years old) provided plasma, from which a measure of endotoxemia was determined [i.e., the ratio of lipopolysaccharide binding protein (LBP) to soluble cluster of differentiation 14 receptors (sCD14)]. Participants performed an array of laboratory and ambulatory cognit

SUBMITTER: McDonnell SC 

PROVIDER: S-EPMC11577790 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature