Sex hormones and reproductive factors with cardiac arrhythmia and ECG indices: a mendelian randomization study.

ABSTRACT:

Background

Sex is a determinant of the incidence and etiology of arrhythmia. Observational and basic studies suggest that sex hormones are essential in this process; however, the relationship between sex hormones and arrhythmia remains unclear. Mendelian randomization (MR) was used to investigate the causal relationships between sex hormone levels, arrhythmia, and electrocardiographic (ECG) indices.

Methods

Large genome-wide association studies (GWAS) data on sex hormones, stratified by sex, from the UK biobank consortium, were used as exposure data, and data on atrial fibrillation (AF), atrioventricular block, sick sinus syndrome, paroxysmal tachycardia, and ECG indices were obtained from the FinnGen consortium and summarized large GWAS data. Inverse variance weighting or w

SUBMITTER: Wang X 

PROVIDER: S-EPMC11577811 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature