Association of serum creatinine-cystatin C ratio with all-cause, cardiovascular and cancer mortality in US adults: a nationwide cohort study.

ABSTRACT:

Objective

To investigate the association of serum creatinine-cystatin C ratio (Cr/CysC) with long-term all-cause mortality and cause-specific (cardiovascular and cancer) mortality among US general adults.

Methods

This nationally representative cohort study included adults in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Participants were linked to National Death Index data from the survey date through December 31, 2019. Weighted Cox proportional hazards regression models were used to calculate hazard ratios and 95% confidence intervals (CIs), and restricted cubic splines and stratified analyses were also performed.

Results

A total of 12,914 participants were included in this study (mean [SD] age, 45.3 [17.3] years; males, 48.9%). Dur

SUBMITTER: Wang S 

PROVIDER: S-EPMC11577820 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature